Invention Grant
- Patent Title: Methods and compositions for modulating P300/CBP activity
- Patent Title (中): 调节P300 / CBP活性的方法和组合物
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Application No.: US13905222Application Date: 2013-05-30
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Publication No.: US09138439B2Publication Date: 2015-09-22
- Inventor: Ronen Marmorstein , Xin Liu , Philip A. Cole , Ling Wang , Erin M. Bowers , David J. Meyers , Chandrani Mukherjee
- Applicant: The Wistar Institute , The Johns Hopkins University
- Applicant Address: US PA Philadelphia US MD Baltimore
- Assignee: The Wistar Institute,The Johns Hopkins University
- Current Assignee: The Wistar Institute,The Johns Hopkins University
- Current Assignee Address: US PA Philadelphia US MD Baltimore
- Agency: Licata & Tyrrell P.C.
- Main IPC: C07D231/00
- IPC: C07D231/00 ; C07D231/06 ; C07D307/00 ; C07D317/00 ; C07D323/02 ; A61K31/5585 ; A61K31/4025 ; A61K31/402 ; A61K31/4015 ; C12N9/10 ; C12Q1/48 ; C40B30/02 ; C07D405/06
Abstract:
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.
Public/Granted literature
- US20130345267A1 METHODS AND COMPOSITIONS FOR MODULATING P300/CBP ACTIVITY Public/Granted day:2013-12-26
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