Invention Grant
US09139517B2 Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
有权
（R） - 巴氯芬前药的无水半水合物结晶形式，合成方法和使用方法
- Patent Title: Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
- Patent Title (中): （R） - 巴氯芬前药的无水半水合物结晶形式，合成方法和使用方法
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Application No.: US14076406Application Date: 2013-11-11
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Publication No.: US09139517B2Publication Date: 2015-09-22
- Inventor: Stephen P. Raillard , Suresh K. Manthati , Sudhir Joshi
- Applicant: XenoPort, Inc.
- Applicant Address: US CA Santa Clara
- Assignee: XenoPort, Inc.
- Current Assignee: XenoPort, Inc.
- Current Assignee Address: US CA Santa Clara
- Agency: Polsinelli PC
- Main IPC: C07C271/22
- IPC: C07C271/22
Abstract:
Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
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