An actuator for actuating a plunger of a valve is provided. The actuator has an inlet and includes first and second hollow caps. A main actuation assembly is provided between the caps. The main actuation assembly includes a deformable diaphragm; first and second chambers, static sealing elements and a main piston movable between actuated and unactuated positions. A biasing mechanism biases the piston in the unactuated position. When pressurized gas is flown through the inlet and/or drawn from the outlet of the actuator, the first chamber expands, moving the main piston from the unactuated position to the actuated position, an actuating stem connected to the main piston thereby sliding within a channel provided in the bottom cap. Stackable actuating assemblies can also be used between the caps. Using static sealing elements advantageously avoids friction between moving parts.