The present invention extends to methods, systems, and computer program products for musical learning and interaction. Embodiments include presenting a musical instrument at a user interface. The user interface includes a video layer. The video layer is configured to visually present one or more frames of video. The user interface also includes a virtual musical instrument. The virtual musical instrument is overlaid over a least a portion of the video layer, and is at least partially transparent. As such, the portion of the video layer over which the virtual musical instrument is overlaid shows through the virtual musical instrument.