Invention Grant
- Patent Title: Isoxazolines as inhibitors of fatty acid amide hydrolase
- Patent Title (中): 异恶唑啉作为脂肪酸酰胺水解酶的抑制剂
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Application No.: US12782650Application Date: 2010-05-18
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Publication No.: US09149465B2Publication Date: 2015-10-06
- Inventor: Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
- Applicant: Mark L. Behnke , Alfredo C. Castro , Lawrence K. Chan , Catherine A. Evans , Louis Grenier , Michael J. Grogan , Yves Leblanc , Tao Liu , Stephane Peluso , Daniel A. Snyder , Thomas T. Tibbitts
- Applicant Address: US MA Cambridge
- Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Jones Day
- Main IPC: C07D261/04
- IPC: C07D261/04 ; A61K31/5377 ; A61K31/42 ; A61K31/4245 ; A61K31/4439 ; A61K31/4709 ; A61K31/501 ; A61K31/506 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D471/04

Abstract:
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
Public/Granted literature
- US20110028478A1 ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE Public/Granted day:2011-02-03
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