Invention Grant
US09149468B2 Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid
有权
制备的([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和2- [2 - [(2,6-二氯苯基) - 氨基] - 苯基] -醋酸
- Patent Title: Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid
- Patent Title (中): 制备的([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和2- [2 - [(2,6-二氯苯基) - 氨基] - 苯基] -醋酸
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Application No.: US13992247Application Date: 2011-12-20
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Publication No.: US09149468B2Publication Date: 2015-10-06
- Inventor: Christoph Martin Hoock , Asal Qadan , Bernd Terhaag
- Applicant: Christoph Martin Hoock , Asal Qadan , Bernd Terhaag
- Applicant Address: DE Ulm
- Assignee: TEVA GmbH
- Current Assignee: TEVA GmbH
- Current Assignee Address: DE Ulm
- Agent Gudrun E. Huckett
- Priority: DE102010063612 20101220
- International Application: PCT/EP2011/073441 WO 20111220
- International Announcement: WO2012/084975 WO 20120628
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/196 ; C07C229/42 ; C07D213/75
![Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid](/abs-image/US/2015/10/06/US09149468B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are based on inflammatory processes. The novel multicomponent crystals contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid (diclofenac) as the sole active ingredient combination and can be produced by dissolving the two components in a molar ratio of 1.0:0.9 to 1.0:1.1 in an inert organic solvent and subsequently crystallizing the complex compound.
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