Invention Grant
US09149468B2 Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid 有权
制备的([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和2- [2 - [(2,6-二氯苯基) - 氨基] - 苯基] -醋酸

  • Patent Title: Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid
  • Patent Title (中): 制备的([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和2- [2 - [(2,6-二氯苯基) - 氨基] - 苯基] -醋酸
  • Application No.: US13992247
    Application Date: 2011-12-20
  • Publication No.: US09149468B2
    Publication Date: 2015-10-06
  • Inventor: Christoph Martin HoockAsal QadanBernd Terhaag
  • Applicant: Christoph Martin HoockAsal QadanBernd Terhaag
  • Applicant Address: DE Ulm
  • Assignee: TEVA GmbH
  • Current Assignee: TEVA GmbH
  • Current Assignee Address: DE Ulm
  • Agent Gudrun E. Huckett
  • Priority: DE102010063612 20101220
  • International Application: PCT/EP2011/073441 WO 20111220
  • International Announcement: WO2012/084975 WO 20120628
  • Main IPC: A61K31/44
  • IPC: A61K31/44 A61K31/196 C07C229/42 C07D213/75
Multicomponent crystals made ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid
Abstract:
The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are based on inflammatory processes. The novel multicomponent crystals contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid (diclofenac) as the sole active ingredient combination and can be produced by dissolving the two components in a molar ratio of 1.0:0.9 to 1.0:1.1 in an inert organic solvent and subsequently crystallizing the complex compound.
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