Invention Grant
US09149523B2 Compositions and methods for treating cancer and neurodegenerative diseases
有权
用于治疗癌症和神经变性疾病的组合物和方法
- Patent Title: Compositions and methods for treating cancer and neurodegenerative diseases
- Patent Title (中): 用于治疗癌症和神经变性疾病的组合物和方法
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Application No.: US13995096Application Date: 2011-12-14
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Publication No.: US09149523B2Publication Date: 2015-10-06
- Inventor: Adi Kimchi , Rodrigo Carlessi
- Applicant: Adi Kimchi , Rodrigo Carlessi
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2011/000950 WO 20111214
- International Announcement: WO2012/081017 WO 20120621
- Main IPC: G01N33/533
- IPC: G01N33/533 ; G01N33/535 ; G01N33/483 ; C12N9/00 ; A61K39/395 ; G01N33/50 ; C12Q1/48
Abstract:
The present invention relates to compositions and methods for regulating ROC-mediated death-associated protein kinase (DAPk) activity. The compositions and methods of the present invention are useful for treating or ameliorating cancer as well as pathologies associated with neuronal cell death, such as epilepsy and hypoxia/ischemia acute brain injury. The present invention further relates to screening methods for identifying agents that regulate ROC-mediated DAPk activation.
Public/Granted literature
- US20130266582A1 COMPOSITIONS AND METHODS FOR TREATING CANCER AND NEURODEGENERATIVE DISEASES Public/Granted day:2013-10-10
Information query
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