Invention Grant
- Patent Title: Polymer conjugate of folic acid or folic acid derivative
- Patent Title (中): 叶酸或叶酸衍生物的聚合物缀合物
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Application No.: US12991041Application Date: 2009-04-28
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Publication No.: US09149540B2Publication Date: 2015-10-06
- Inventor: Takeshi Nakanishi , Kazuhisa Hara , Chieko Seno
- Applicant: Takeshi Nakanishi , Kazuhisa Hara , Chieko Seno
- Applicant Address: JP Tokyo
- Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nields, Lemack & Frame, LLC
- Priority: JP2008-122233 20080508
- International Application: PCT/JP2009/058325 WO 20090428
- International Announcement: WO2009/136572 WO 20091112
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K47/34 ; A61K31/785 ; C08G69/10 ; C08G69/40 ; C08G69/48

Abstract:
Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.]
Public/Granted literature
- US20110294980A1 Polymer Conjugate Of Folic Acid Or Folic Acid Derivative Public/Granted day:2011-12-01
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