Invention Grant
- Patent Title: Compound having affinity for amyloid
- Patent Title (中): 对淀粉样蛋白具有亲和力的化合物
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Application No.: US14118317Application Date: 2012-05-18
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Publication No.: US09149546B2Publication Date: 2015-10-06
- Inventor: Yuki Okumura , Yoshifumi Maya , Yoshinari Shoyama , Takako Onishi
- Applicant: Yuki Okumura , Yoshifumi Maya , Yoshinari Shoyama , Takako Onishi
- Applicant Address: JP Tokyo
- Assignee: NIHON MEDI-PHYSICS CO., LTD.
- Current Assignee: NIHON MEDI-PHYSICS CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery LLP
- Priority: JP2011-114198 20110520
- International Application: PCT/JP2012/062778 WO 20120518
- International Announcement: WO2012/161116 WO 20121129
- Main IPC: C07F15/00
- IPC: C07F15/00 ; C07D491/02 ; C07D471/02 ; C07D498/02 ; C07D513/02 ; C07D515/02 ; A61K31/44 ; A61K51/00 ; A61K51/04 ; C07D471/04 ; C07F7/22

Abstract:
A compound that is effective as a diagnostic imaging probe that targets amyloid including is represented by the following formula (1), or salt thereof: wherein R1 is a radioactive halogen substituent, A1 and A2 independently represent CH or N. A diagnostic agent for Alzheimer's disease includes the compound represented by the above formula or a salt thereof. The above compound and the above diagnostic agent for Alzheimer's disease transfer into brain after administration, and indicate good accumulation on amyloid deposited in the brain.
Public/Granted literature
- US20140228569A1 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID Public/Granted day:2014-08-14
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