Invention Grant
- Patent Title: Process for the preparation of nateglinide
- Patent Title (中): 那格列奈的制备方法
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Application No.: US13703758Application Date: 2011-06-14
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Publication No.: US09150499B2Publication Date: 2015-10-06
- Inventor: Rajendra Narayanrao Kankan , Dharmaraj Ramachandra Rao , Dilip Ramdas Birari
- Applicant: Rajendra Narayanrao Kankan , Dharmaraj Ramachandra Rao , Dilip Ramdas Birari
- Applicant Address: IN Mumbai
- Assignee: Cipla Limited
- Current Assignee: Cipla Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN1793/MUM/2010 20100614
- International Application: PCT/GB2011/000895 WO 20110614
- International Announcement: WO2011/157986 WO 20111222
- Main IPC: C07C229/00
- IPC: C07C229/00 ; C07C231/12
Abstract:
The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (−)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.
Public/Granted literature
- US20130165686A1 Process for the Preparation of Nateglinide Public/Granted day:2013-06-27
Information query
