Invention Grant
- Patent Title: Dual-acting antihypertensive agents
- Patent Title (中): 双作用抗高血压药
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Application No.: US14521689Application Date: 2014-10-23
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Publication No.: US09150514B2Publication Date: 2015-10-06
- Inventor: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: A61K31/4174
- IPC: A61K31/4174 ; A61K31/415 ; A61K31/4196 ; A61K31/4412 ; C07D213/89 ; C07D213/64 ; C07D231/14 ; C07D233/64 ; C07D233/68 ; C07D233/70 ; C07D233/90 ; C07D249/08 ; C07D401/12 ; C07D403/10 ; C07D513/04 ; C07D513/14 ; A61K31/417 ; A61K31/4188 ; A61K45/00 ; C07D207/46 ; C07D255/02 ; A61K31/4164 ; A61K45/06 ; C07D207/36
Abstract:
The invention is directed to methods for treating hypertension or heart failure using compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. In particular embodiments, the invention uses compounds having formula IIIa, IVa, Va: These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity.
Public/Granted literature
- US20150065543A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS Public/Granted day:2015-03-05
Information query
IPC分类:
