Invention Grant
- Patent Title: Pure intermediate
- Patent Title (中): 纯中间体
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Application No.: US13818815Application Date: 2011-08-26
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Publication No.: US09150524B2Publication Date: 2015-10-06
- Inventor: Vinayak Govind Gore , Vinay Kumar Shukla , Sandeep Mekde , Suresh Hasbe , Shreyas Bhandari , Dhananjay Shinde , Madhukar Shaligram Patil
- Applicant: Vinayak Govind Gore , Vinay Kumar Shukla , Sandeep Mekde , Suresh Hasbe , Shreyas Bhandari , Dhananjay Shinde , Madhukar Shaligram Patil
- Applicant Address: GB Albany Gate, Darkes Lane, Potters Bar, Hertfordshire
- Assignee: Generics [UK] Limited
- Current Assignee: Generics [UK] Limited
- Current Assignee Address: GB Albany Gate, Darkes Lane, Potters Bar, Hertfordshire
- Agency: Joe Liebeschuetz (Alston & Bird LLP)
- Priority: IN2395/MUM/2010 20100827
- International Application: PCT/GB2011/051611 WO 20110826
- International Announcement: WO2012/025762 WO 20120301
- Main IPC: C07D249/08
- IPC: C07D249/08 ; A61K31/4196
Abstract:
The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.
Public/Granted literature
- US20130203826A1 Pure Intermediate Public/Granted day:2013-08-08
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