Invention Grant
US09150528B2 Compound having detrusor muscle-contracting activity and urethral sphincter muscle-relaxing activity
有权
具有逼尿肌肌收缩活性和尿道括约肌肌肉放松活性的化合物
- Patent Title: Compound having detrusor muscle-contracting activity and urethral sphincter muscle-relaxing activity
- Patent Title (中): 具有逼尿肌肌收缩活性和尿道括约肌肌肉放松活性的化合物
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Application No.: US14178901Application Date: 2014-02-12
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Publication No.: US09150528B2Publication Date: 2015-10-06
- Inventor: Kazuyuki Ohmoto , Akihiro Kinoshita , Hidekazu Matsuya , Hiroki Okada
- Applicant: ONO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Osaka
- Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2009-139657 20090610; JP2009-256008 20091109
- Main IPC: C07D277/56
- IPC: C07D277/56 ; A61K31/426 ; A61K47/48 ; B82Y5/00 ; C07D277/20 ; C07D277/36 ; C08B37/00 ; A61K45/06

Abstract:
Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.
Public/Granted literature
- US20140171387A1 COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY Public/Granted day:2014-06-19
Information query