Invention Grant
- Patent Title: Precursor used for labeling hepatorcyte receptor and containing trisaccharide and diamide demercaptide ligand, method for preparing the same, radiotracer and pharmaceutical composition of the same
- Patent Title (中): 用于标记肝细胞受体并含有三糖和二酰胺十氯过硫酸配体的前体，其制备方法，放射性示踪剂及其药物组合物
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Application No.: US13556486Application Date: 2012-07-24
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Publication No.: US09150602B2Publication Date: 2015-10-06
- Inventor: Show-Wen Liu , Yu Chang , Cheng-Fang Hsu , Ming-Che Tsai , Tsung-Hsien Chiang , Yueh-Feng Deng , Kuei-Lin Lu , Chih-Yuan Lin , Da-Ming Wang , Ching-Yun Li
- Applicant: Show-Wen Liu , Yu Chang , Cheng-Fang Hsu , Ming-Che Tsai , Tsung-Hsien Chiang , Yueh-Feng Deng , Kuei-Lin Lu , Chih-Yuan Lin , Da-Ming Wang , Ching-Yun Li
- Applicant Address: TW Taoyuan County
- Assignee: Atomic Energy Council, Institute of Nuclear Energy Research
- Current Assignee: Atomic Energy Council, Institute of Nuclear Energy Research
- Current Assignee Address: TW Taoyuan County
- Agency: Rosenberg, Klein & Lee
- Main IPC: C07H15/18
- IPC: C07H15/18 ; C07H1/00
Abstract:
A precursor used for labeling hepatocyte receptors and applied to radiotracers for imaging or pharmaceutical compositions for liver cancers is revealed. The precursor is a bifunctional compound. The bifunctional group includes a trisaccharide structure and a diamide dimercaptide (N2S2) ligand. The trisaccharide has high affinity to asialoglycoprotein receptors (ASGPR) on surfaces of hepatocytes while N2S2 ligand reacts with radioisotopes to form neutral complexes. Thus the precursor stays on surfaces of hepatocytes to provide radioisotope labeling or treatment effect of liver cancers.
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