Invention Grant
- Patent Title: 2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases
- Patent Title (中): 2'-氰基取代的核苷衍生物及其用于治疗病毒性疾病的方法
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Application No.: US14111688Application Date: 2012-04-11
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Publication No.: US09150603B2Publication Date: 2015-10-06
- Inventor: Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Angela Kerekes , Frank Bennett , Ying Huang , Latha Nair , Dmitri Pissarnitski , Vishal Verma , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
- Applicant: Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Angela Kerekes , Frank Bennett , Ying Huang , Latha Nair , Dmitri Pissarnitski , Vishal Verma , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Jeffrey P. Bergman; Laura M. Ginkel
- International Application: PCT/US2012/033028 WO 20120411
- International Announcement: WO2012/142093 WO 20121018
- Main IPC: C07H19/06
- IPC: C07H19/06 ; C07H19/20 ; C07H19/10 ; C07H19/12 ; C07H19/16 ; C07H19/04 ; C07H19/207 ; C07H19/11 ; C07H19/213 ; A61K31/7056 ; A61K31/7068 ; A61K31/7076 ; A61K45/06
Abstract:
The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
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