Invention Grant
US09150605B2 Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
有权
包含交替的2'-修饰核苷的组合物用于基因调控
- Patent Title: Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
- Patent Title (中): 包含交替的2'-修饰核苷的组合物用于基因调控
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Application No.: US10860265Application Date: 2004-06-03
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Publication No.: US09150605B2Publication Date: 2015-10-06
- Inventor: Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- Applicant: Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Baker Hofstetler
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/00 ; C07H21/04 ; C12N15/11 ; C12N15/113
Abstract:
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
Public/Granted literature
- US20050080246A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation Public/Granted day:2005-04-14
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