Invention Grant
- Patent Title: RNA targeting compounds and methods for making and using same
- Patent Title (中): RNA靶向化合物及其制备和使用方法
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Application No.: US12072291Application Date: 2008-02-25
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Publication No.: US09150612B2Publication Date: 2015-10-06
- Inventor: Matthew D. Disney
- Applicant: Matthew D. Disney
- Applicant Address: US NY Amherst
- Assignee: The Research Foundation of State University of New York
- Current Assignee: The Research Foundation of State University of New York
- Current Assignee Address: US NY Amherst
- Agency: Hodgson Russ LLP
- Main IPC: C07K4/00
- IPC: C07K4/00 ; C07D249/04 ; A61K31/7008 ; C07K9/00 ; C07K14/00

Abstract:
Disclosed are RNA targeting compounds having the formula: wherein j is an integer from 1 to 100; each i is the same or different and is zero or an integer from 1 to 100; each Z1 represents the same or different linking moiety; each R1 is the same or different and represents an alkyl group or an aryl group; each Q1 represents the same or different RNA binding ligand; Q2 is an alkyl group; Q3 is a halogen, an alkyl group, an aryl group, or an amine. Also disclosed are RNA targeting compounds that include a polymer backbone and two or more pendant RNA binding ligands that are bound to the polymer backbone. Methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed, as are compounds that can be used to prepare the subject RNA targeting compounds.
Public/Granted literature
- US20080227213A1 RNA targeting compounds and methods for making and using same Public/Granted day:2008-09-18
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