Invention Grant
US09150634B2 Epitopes of the human PDGF receptor able to bind human auto-antibodies, antibodies and uses thereof
有权
能够结合人自身抗体的人PDGF受体的表位，抗体及其用途
- Patent Title: Epitopes of the human PDGF receptor able to bind human auto-antibodies, antibodies and uses thereof
- Patent Title (中): 能够结合人自身抗体的人PDGF受体的表位，抗体及其用途
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Application No.: US13812764Application Date: 2011-07-29
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Publication No.: US09150634B2Publication Date: 2015-10-06
- Inventor: Gianluca Moroncini , Ada Funaro , Armando Gabrielli , Vittorio Enrico Avvedimento , Silvia Svegliati Baroni , Mariarosaria Santillo , Roberto Paterno′
- Applicant: Gianluca Moroncini , Ada Funaro , Armando Gabrielli , Vittorio Enrico Avvedimento , Silvia Svegliati Baroni , Mariarosaria Santillo , Roberto Paterno′
- Agency: Lucas & Mercanti, LLP
- International Application: PCT/EP2011/063165 WO 20110729
- International Announcement: WO2012/013813 WO 20120202
- Main IPC: C07K7/00
- IPC: C07K7/00 ; C07K14/705 ; C07K14/71 ; C07K16/28 ; C07K5/10 ; C07K7/06 ; C07K7/08
Abstract:
The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.
Public/Granted literature
- US20130130268A1 EPITOPES OF THE HUMAN PDGF RECEPTOR ABLE TO BIND HUMAN AUTO-ANTIBODIES, ANTIBODIES AND USES THEREOF Public/Granted day:2013-05-23
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