Invention Grant
US09150656B2 Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
有权
与B7-H3反应的抗体，其免疫活性片段及其用途
- Patent Title: Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
- Patent Title (中): 与B7-H3反应的抗体，其免疫活性片段及其用途
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Application No.: US13581340Application Date: 2011-03-01
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Publication No.: US09150656B2Publication Date: 2015-10-06
- Inventor: Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
- Applicant: Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
- Applicant Address: US MD Rockville
- Assignee: MacroGenics, Inc.
- Current Assignee: MacroGenics, Inc.
- Current Assignee Address: US MD Rockville
- Agency: AuerbachSchrot LLC
- Agent William C. Schrot
- International Application: PCT/US2011/026689 WO 20110301
- International Announcement: WO2011/109400 WO 20110909
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/30 ; C07K16/28 ; A61K39/395 ; A61K45/06 ; C07K16/44 ; G01N33/68 ; A61K39/00
Abstract:
The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
Public/Granted literature
- US20130149236A1 Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof Public/Granted day:2013-06-13
Information query
IPC分类:
