Invention Grant
- Patent Title: Beta-glucosidase variants
- Patent Title (中): β-葡糖苷酶变体
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Application No.: US14540422Application Date: 2014-11-13
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Publication No.: US09150843B2Publication Date: 2015-10-06
- Inventor: Xiyun Zhang , Jie Yang , Dipnath Baidyaroy , Sally R. Postlethwaite , Attila Andor , Louis A. Clark , Lisa Marie Newman
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/42
- IPC: C12N9/42 ; C12N9/24
Abstract:
The invention relates to recombinantly produced β-glucosidase variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
Public/Granted literature
- US20150064766A1 BETA-GLUCOSIDASE VARIANTS Public/Granted day:2015-03-05
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