Invention Grant
- Patent Title: Targeted alteration of DNA
- Patent Title (中): 靶向改变DNA
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Application No.: US13991060Application Date: 2011-11-25
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Publication No.: US09150854B2Publication Date: 2015-10-06
- Inventor: Paul Bundock , Franck Lhuissier
- Applicant: Paul Bundock , Franck Lhuissier
- Applicant Address: NL Wageningen
- Assignee: Keygene N.V.
- Current Assignee: Keygene N.V.
- Current Assignee Address: NL Wageningen
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP.
- Priority: NL2005808 20101203
- International Application: PCT/NL2011/050804 WO 20111125
- International Announcement: WO2012/074385 WO 20120607
- Main IPC: C12N15/01
- IPC: C12N15/01 ; C12N15/113 ; C12N15/10
Abstract:
The current invention relates to a method for targeted alteration of acceptor DNA, for example duplex acceptor DNA. The method comprises the use of an oligonucleotide having at least one mismatch relative to the targeted (duplex) acceptor DNA. The mismatch is located at specific positions within said oligonucleotide. Also provided is a kit that comprises instructions for performing the method according to the inventions, and in a preferred embodiment, comprises an oligonucleotide suitable for use in the method.
Public/Granted literature
- US20140004607A1 TARGETED ALTERATION OF DNA Public/Granted day:2014-01-02
Information query
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