Invention Grant
- Patent Title: siRNA targeting VEGFA and methods for treatment in vivo
- Patent Title (中): 靶向VEGFA的siRNA和体内治疗方法
-
Application No.: US14010749Application Date: 2013-08-27
-
Publication No.: US09150862B2Publication Date: 2015-10-06
- Inventor: Anja Smith , Angela Reynolds , Jon E. Chatterton , Xinyu Zhang
- Applicant: Anja Smith , Angela Reynolds , Jon E. Chatterton , Xinyu Zhang
- Applicant Address: US MA Waltham US WI Madison
- Assignee: Thermo Fisher Scientific Inc.,Arrowhead Research Corporation
- Current Assignee: Thermo Fisher Scientific Inc.,Arrowhead Research Corporation
- Current Assignee Address: US MA Waltham US WI Madison
- Agency: Dorf & Nelson LLP
- Agent Scott D. Locke, Esq.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; A61K31/713
Abstract:
Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.
Public/Granted literature
- US20140031414A1 SIRNA TARGETING VEGFA AND METHODS FOR TREATMENT IN VIVO Public/Granted day:2014-01-30
Information query
