A rotation module with a linked plugging and unplugging design is applied to a host case for installation and disassembly. The rotation module includes: a housing, for accommodating a data storage unit electrically connected to a cable; a placement assembly, for guiding the housing along a first direction to install or disassemble the housing; a rotation assembly, for rotatably combining the housing and the placement assembly so that the housing is capable of rotating along a second direction; and a linkage assembly, having a first end and a second end, with a plug assembly of the cable assembled to the second end. In response to the housing rotated along the second direction, the second end of the linkage assembly moves in a linked manner along the first direction and enables the plug assembly to plug into or unplug from a slot of a motherboard.