The invention relates to a technical field of light emitting diodes (LEDs), in particular to a self-adaptive drive circuit and an LED lamp with the same. The LED lamp comprises a plurality of series LED lamp strings, and each LED lamp string comprises at least one series LED lamp bead; and the self-adaptive drive circuit comprises a rectifying unit, a current limiting unit, a voltage detection and connectivity control unit and at least one controllable switch unit. According to the self-adaptive drive circuit and the LED lamp with the same, the LEDs can be driven normally in an extremely simple drive mode, which can work without using complex constant current drive circuit and electrolytic capacitor that is life limiting. At the same time, the stroboflash phenomenon is eliminated, the power factor is improved, harmonic distortion is reduced, electromagnetic interference is eliminated, and the cost is reduced.