Invention Grant
US09155697B2 Stable liquid compositions for treating stomatitis comprising epidermal growth factor
有权
用于治疗包含表皮生长因子的口腔炎的稳定液体组合物
- Patent Title: Stable liquid compositions for treating stomatitis comprising epidermal growth factor
- Patent Title (中): 用于治疗包含表皮生长因子的口腔炎的稳定液体组合物
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Application No.: US12444961Application Date: 2007-10-09
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Publication No.: US09155697B2Publication Date: 2015-10-13
- Inventor: Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
- Applicant: Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
- Applicant Address: KR
- Assignee: DAEWOONG CO., LTD.
- Current Assignee: DAEWOONG CO., LTD.
- Current Assignee Address: KR
- Agency: Cantor Colburn LLP
- Priority: KR10-2006-0097734 20061009
- International Application: PCT/KR2007/004911 WO 20071009
- International Announcement: WO2008/044852 WO 20080417
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/485 ; A61K9/00 ; A61K47/10

Abstract:
Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.
Public/Granted literature
- US20100035809A1 STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR Public/Granted day:2010-02-11
Information query
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