An integrated circuit includes circuitry organized into sub-blocks, and power supply selection circuitry operative to selectively adjust the connectivity of power supply terminals of the sub-blocks. When the integrated circuit is operating in an active mode, the power supply selection circuitry couples the sub-blocks in parallel between upper and lower active-mode power supplies; when the integrated circuit is operating in a standby mode, the power supply selection circuitry couples two or more sub-blocks in series between upper and lower standby-mode power supplies. Additionally, in standby mode, isolation circuitry within a sub-block is activated to isolate circuitry within the sub-block from input or output terminals of the sub-block.