Methods and systems are disclosed for efficient cancellation of crosstalk between signals transmitted over multiple signal paths. Symmetry is induced on the signals transmitted over the signal paths such that the crosstalk matrix becomes a matrix with structure. Such structured matrix may be a circulant matrix of which the inverse may be applied efficiently to transmitted symbols or received symbols. Application of such inverse may comprise the fast Fourier transform. Applications of the methods and systems disclosed include chip-to-chip communications, on-chip communications, communication over cables and storage of information.