A method, system and device are provided for avoiding in-device coexistence interference between different radio technologies deployed in adjacent bands on the same device by controlling and separating the LTE signaling and the non-LTE signaling using dedicated time intervals to separate LTE signaling from non-LTE signaling. In addition, coexistence mode handover procedures are provided which use threshold-based triggering events to avoid coexistence interference and to prevent ping-pong effects by establishing a “keeping time” parameter so that a non-interfering network node does not switch back to an interfering network node after handoff. Coexistence interference is also avoided by providing a hybrid automatic repeat request (HARQ) mechanism which accounts for coexistence interference by providing a fixed or variable on-interval parameter and an activity parameter indicating whether non-LTE activity is present to maximize a time interval for non-LTE devices without interference from LTE activity on the same device.