Invention Grant
- Patent Title: Crystalline active ingredient microparticles, method for producing the same and use thereof in drugs
- Patent Title (中): 结晶活性成分微粒，其制备方法及其在药物中的应用
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Application No.: US13058168Application Date: 2009-06-30
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Publication No.: US09173843B2Publication Date: 2015-11-03
- Inventor: Detlef Grawe , Sabine Gliesing , Robert Eilers
- Applicant: Detlef Grawe , Sabine Gliesing , Robert Eilers
- Applicant Address: DE Jena
- Assignee: Jesalis Pharma GMBH
- Current Assignee: Jesalis Pharma GMBH
- Current Assignee Address: DE Jena
- Agency: Patterson Thuente Pedersen, P.A.
- Priority: DE102008037025 20080808
- International Application: PCT/EP2009/004724 WO 20090630
- International Announcement: WO2010/015298 WO 20100211
- Main IPC: A61K31/58
- IPC: A61K31/58 ; A61K31/56 ; A61P5/00 ; C07J53/00 ; C07J1/00 ; C07J7/00 ; C07J3/00 ; A61K9/16 ; H04R5/00
Abstract:
A method for producing highly crystalline and stable microparticles of an active substance with a very narrow size distribution. The microparticles being crystallized out of a suspension made of primary particles of the active substance, a solution of the active substance, a non-solvent for the active substance and inert formed pieces. The resulting microparticles hare are highly stable largely independent of the physiochemical properties of the active substance and can be especially suitable for fast release dosage forms of pharmaceuticals.
Public/Granted literature
- US20110144071A1 CRYSTALLINE ACTIVE INGREDIENT MICROPARTICLES, METHOD FOR PRODUCING THE SAME AND USE THEREOF IN DRUGS Public/Granted day:2011-06-16
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