Invention Grant
- Patent Title: Mediators of hedgehog signaling pathways, compositions and uses related thereto
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Application No.: US12769112Application Date: 2010-04-28
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Publication No.: US09173869B2Publication Date: 2015-11-03
- Inventor: Oivin M. Guicherit , Lee Rubin
- Applicant: Oivin M. Guicherit , Lee Rubin
- Applicant Address: US MA Cambridge
- Assignee: CURIS, INC.
- Current Assignee: CURIS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Millen, White, Zelano & Branigan, P.C.
- Main IPC: A61K31/381
- IPC: A61K31/381 ; A61K31/517 ; C07D239/91
Abstract:
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
Public/Granted literature
- US20110077256A1 MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO Public/Granted day:2011-03-31
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