Invention Grant
US09173893B2 Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
有权
用于治疗癌症和病毒感染的嘌呤核苷单磷酸前药
- Patent Title: Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections
- Patent Title (中): 用于治疗癌症和病毒感染的嘌呤核苷单磷酸前药
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Application No.: US14032496Application Date: 2013-09-20
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Publication No.: US09173893B2Publication Date: 2015-11-03
- Inventor: Jong Hyun Cho , Steven J. Coats , Raymond F. Schinazi , Hongwang Zhang , Longhu Zhou
- Applicant: Cocrystal Pharma, Inc. , Emory University
- Applicant Address: US GA Tucker
- Assignee: Cocrystal Pharma, Inc.
- Current Assignee: Cocrystal Pharma, Inc.
- Current Assignee Address: US GA Tucker
- Agency: Andrews Kurth LLP
- Agent David Bradin
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A61K31/7076 ; A61K31/7064 ; A61K31/7042 ; A61K31/706 ; A61K31/708 ; A61K31/7068 ; A61K31/7052 ; A61K31/7028 ; A61K45/06 ; C07H19/173 ; C07H19/20 ; A61K31/675 ; C07D473/16
Abstract:
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
Public/Granted literature
- US20140066395A1 PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS Public/Granted day:2014-03-06
Information query
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