Invention Grant
US09173894B2 Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
有权
使用针对结缔组织生长因子（CTGF）的反义化合物治疗瘢痕疙瘩或肥厚性瘢痕的方法
- Patent Title: Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
- Patent Title (中): 使用针对结缔组织生长因子（CTGF）的反义化合物治疗瘢痕疙瘩或肥厚性瘢痕的方法
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Application No.: US13364547Application Date: 2012-02-02
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Publication No.: US09173894B2Publication Date: 2015-11-03
- Inventor: Nicholas M. Dean , Lincoln Krochmal , Gregory Hardee , J. Gordon Foulkes , Niall O'Donnell , Leroy Young , Mark Jewell
- Applicant: Nicholas M. Dean , Lincoln Krochmal , Gregory Hardee , J. Gordon Foulkes , Niall O'Donnell , Leroy Young , Mark Jewell
- Applicant Address: US NY New York
- Assignee: Excaliard Pharamaceuticals, Inc.
- Current Assignee: Excaliard Pharamaceuticals, Inc.
- Current Assignee Address: US NY New York
- Agent Raquel M. Alvarez
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/7088 ; A61K31/712 ; A61K45/06
Abstract:
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
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