Invention Grant
- Patent Title: Process for preparing polysaccharide-protein conjugate vaccines
- Patent Title (中): 制备多糖 - 蛋白质结合疫苗的方法
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Application No.: US10566898Application Date: 2004-08-06
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Publication No.: US09173931B2Publication Date: 2015-11-03
- Inventor: Ellen Jessouroun , Ivna Alana Freitas Brasileiro Da Silveira , Renata Chagas Bastos , Carl E. Frasch , Che-Hung Robert Lee
- Applicant: Ellen Jessouroun , Ivna Alana Freitas Brasileiro Da Silveira , Renata Chagas Bastos , Carl E. Frasch , Che-Hung Robert Lee
- Applicant Address: US DC Washington BR Rio de Janiero
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,Fiocruz
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,Fiocruz
- Current Assignee Address: US DC Washington BR Rio de Janiero
- Agency: Caesar Rivise, PC
- International Application: PCT/US2004/026431 WO 20040806
- International Announcement: WO2005/037320 WO 20050428
- Main IPC: A61K39/095
- IPC: A61K39/095 ; A61K39/385 ; A61K47/48 ; A61K39/09 ; A61K39/00
Abstract:
Methods for the manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency. Simplified purification processes can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
Public/Granted literature
- US20070110762A1 Process for preparing polysaccharide-protein conjugate vaccines Public/Granted day:2007-05-17
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