A multi-panel sterilization assembly includes a barrier panel formed of a permeable material, a fold protection panel, and at least one panel attachment means. The barrier panel has a first end, an opposed second end, and a midpoint delineating the barrier panel into a content receiving region and a content covering region. Panel attachment means are located at or near edges of the barrier panel to identify the content receiving region. The fold protection panel has a proximal end and an opposed distal end. After the barrier panel is folded at or near the midpoint to bring its second end near its first end and its edges are brought together and secured by the panel attachment means to form a package, the fold protection panel folds at or near a pre-determined fold line to cover at least a portion of the edges of the folded barrier panel.