Invention Grant
- Patent Title: IDO inhibitors
- Patent Title (中): IDO抑制剂
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Application No.: US14264974Application Date: 2014-04-29
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Publication No.: US09174942B2Publication Date: 2015-11-03
- Inventor: Mario R. Mautino , Sanjeev Kumar , Firoz Jaipuri , Jesse Waldo , Tanay Kesharwani , Nicholas N. Vahanian , Charles J. Link , Judith Lalonde , George Prendergast , Alexander Muller , William Malachowski
- Applicant: NewLink Genetics Corporation , Lankeanau Institute for Medical Research
- Applicant Address: US IA Ames
- Assignee: NewLink Genetics Corporation
- Current Assignee: NewLink Genetics Corporation
- Current Assignee Address: US IA Ames
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: A61K31/4174
- IPC: A61K31/4174 ; C07D233/64 ; C07D233/56 ; C07D233/58 ; C07D233/60 ; C07D233/61 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; C07D417/06 ; C07D498/04 ; C07H19/067
Abstract:
Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.
Public/Granted literature
- US20140323740A1 IDO Inhibitors Public/Granted day:2014-10-30
Information query
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