Invention Grant
US09174952B2 Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals
有权
取代的3-噻唑氨基 - 丙酸衍生物及其作为药物的用途
- Patent Title: Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals
- Patent Title (中): 取代的3-噻唑氨基 - 丙酸衍生物及其作为药物的用途
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Application No.: US13559268Application Date: 2012-07-26
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Publication No.: US09174952B2Publication Date: 2015-11-03
- Inventor: Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Klaus Wirth
- Applicant: Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Klaus Wirth
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP11305972 20110726
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D277/54 ; C07D417/04
Abstract:
The present invention relates to compounds of the formulae Ia and Ib, wherein G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20130053402A1 SUBSTITUTED 3-THIAZOLOAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2013-02-28
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