Invention Grant
US09174956B2 Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof
有权
制备3 - （（2S，5S）-4-亚甲基-5-（3-氧代丙基）四氢呋喃-2-基）丙醇衍生物的方法及其有用的中间体
- Patent Title: Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof
- Patent Title (中): 制备3 - （（2S，5S）-4-亚甲基-5-（3-氧代丙基）四氢呋喃-2-基）丙醇衍生物的方法及其有用的中间体
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Application No.: US14365168Application Date: 2012-12-14
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Publication No.: US09174956B2Publication Date: 2015-11-03
- Inventor: Fabio E. S. Souza , Jason A. Bexrud , Ricardo Orprecio , Boris Gorin
- Applicant: ALPHORA RESEARCH INC.
- Applicant Address: CA Mississauga
- Assignee: ALPHORA RESEARCH INC.
- Current Assignee: ALPHORA RESEARCH INC.
- Current Assignee Address: CA Mississauga
- Agency: Grossman, Tucker, Perrceault & Pfleger, PLLC
- International Application: PCT/CA2012/050897 WO 20121214
- International Announcement: WO2013/086634 WO 20130620
- Main IPC: C07D493/04
- IPC: C07D493/04 ; C07D493/08 ; C07D493/10 ; C07D307/12 ; C07D307/20 ; C07D307/28
Abstract:
Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG1 is an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin.
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