Invention Grant
US09174966B2 Crystalline forms of 6-(1H-imidazol-1-yl)-2-phenylquinazoline
有权
6-(1H-咪唑-1-基)-2-苯基喹唑啉的结晶形式
- Patent Title: Crystalline forms of 6-(1H-imidazol-1-yl)-2-phenylquinazoline
- Patent Title (中): 6-(1H-咪唑-1-基)-2-苯基喹唑啉的结晶形式
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Application No.: US13375816Application Date: 2010-06-04
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Publication No.: US09174966B2Publication Date: 2015-11-03
- Inventor: Antonio Giordani , Stefano Mandelli , Francesca Porta , Matteo Ghirri , Lucio Claudio Rovati
- Applicant: Antonio Giordani , Stefano Mandelli , Francesca Porta , Matteo Ghirri , Lucio Claudio Rovati
- Applicant Address: IT Milan
- Assignee: ROTTAPHARM S.P.A.
- Current Assignee: ROTTAPHARM S.P.A.
- Current Assignee Address: IT Milan
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Priority: ITTO2009A0424 20090604
- International Application: PCT/IB2010/052496 WO 20100604
- International Announcement: WO2010/140139 WO 20101209
- Main IPC: C07D403/04
- IPC: C07D403/04 ; A61K31/517 ; A01N43/54

Abstract:
The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2-phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized.
Public/Granted literature
- US20120142713A1 CRYSTALLINE FORMS OF 6-(1H-IMIDAZOL-1-YL)-2-PHENYLQUINAZOLINE Public/Granted day:2012-06-07
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