Invention Grant
US09174968B2 Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by LP-PLA2
有权
用于治疗由LP-PLA2介导的疾病或病症的嘧啶酮化合物
- Patent Title: Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by LP-PLA2
- Patent Title (中): 用于治疗由LP-PLA2介导的疾病或病症的嘧啶酮化合物
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Application No.: US14569970Application Date: 2014-12-15
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Publication No.: US09174968B2Publication Date: 2015-11-03
- Inventor: Yun Jin , Zehong Wan , Qing Zhang
- Applicant: GLAXO GROUP LIMITED
- Applicant Address: GB Brentford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Fang Qian; William R. Majarian
- Priority: WOPCT/CN2010/079465 20101206
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D239/36 ; C07D239/52 ; C07D239/56 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D403/06 ; C07D403/12 ; C07D413/06 ; C07D417/06 ; C07D239/22 ; C07D239/47 ; A61K31/505 ; A61K31/506
Abstract:
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.
Public/Granted literature
- US20150099756A1 PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP-PLA2 Public/Granted day:2015-04-09
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