Invention Grant
US09174977B2 2-azabicyclo[4.1.0]heptane derivatives as orexin receptor antagonists for the treatment of certain disorders
有权
2-氮杂双环[4.1.0]庚烷衍生物作为食欲素受体拮抗剂用于治疗某些疾病
- Patent Title: 2-azabicyclo[4.1.0]heptane derivatives as orexin receptor antagonists for the treatment of certain disorders
- Patent Title (中): 2-氮杂双环[4.1.0]庚烷衍生物作为食欲素受体拮抗剂用于治疗某些疾病
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Application No.: US14386109Application Date: 2013-03-18
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Publication No.: US09174977B2Publication Date: 2015-11-03
- Inventor: Luigi Piero Stasi , Lucio Claudio Rovati
- Applicant: Rottapharm Biotech S.r.l.
- Applicant Address: IT Monza
- Assignee: Rottapharm Biotech S.R.L.
- Current Assignee: Rottapharm Biotech S.R.L.
- Current Assignee Address: IT Monza
- Agency: Jones Day
- Priority: ITMI2012A0424 20120319
- International Application: PCT/EP2013/055548 WO 20130318
- International Announcement: WO2013/139730 WO 20130926
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D405/00 ; C07D417/14 ; C07D401/14 ; C07D401/10
![2-azabicyclo[4.1.0]heptane derivatives as orexin receptor antagonists for the treatment of certain disorders](/abs-image/US/2015/11/03/US09174977B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides compounds of formula (I) including stereoisomers or a racemate or a mixture or a pharmaceutically acceptable salt thereof: wherein X is NH, or O; Q is 5-6 membered heteroaryl group, which may be substituted by one or more substituents independently selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; A is phenyl or a 5-6 heteroaryl group, which may be substituted by one or more substituents independently selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; B may assume different meanings from A and is phenyl or a 5-6 membered heteroaryl group, which may be substituted by one or more substituents independently selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; and processes for their preparation, pharmaceutical compositions containing them and their use as dual antagonists of the Orexin 1 and Orexin 2 receptors.
Public/Granted literature
- US20150065523A1 CHEMICAL COMPOUNDS Public/Granted day:2015-03-05
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