Invention Grant
US09175002B2 Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
有权
双重酪氨酰-DNA磷酸二酯酶I（Tdp1） - 异构酶I（Top1）抑制剂的合成与应用
- Patent Title: Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
- Patent Title (中): 双重酪氨酰-DNA磷酸二酯酶I（Tdp1） - 异构酶I（Top1）抑制剂的合成与应用
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Application No.: US14537630Application Date: 2014-11-10
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Publication No.: US09175002B2Publication Date: 2015-11-03
- Inventor: Mark S. Cushman , Trung X. Nguyen , Martin M. Conda-Sheridan , Yves George Pommier
- Applicant: Purdue Research Foundation
- Applicant Address: US IN West Lafayette
- Assignee: Purdue Research Foundation
- Current Assignee: Purdue Research Foundation
- Current Assignee Address: US IN West Lafayette
- Agency: Zedek Latzer Baratz LLP
- Agent Mark S. Cohen; Pearl Cohen
- Main IPC: C07D221/22
- IPC: C07D221/22 ; A61K31/44 ; C07D491/056 ; C07D221/18 ; C07D401/06
Abstract:
The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.
Public/Granted literature
- US20150133445A1 SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (Tdp1) - TOPOISOMERASE I (Top1) INHIBITORS Public/Granted day:2015-05-14
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