Invention Grant
US09175011B2 Morpholino substituted urea or carbamate derivatives as MTOR inhibitors
有权
吗啉取代的脲或氨基甲酸酯衍生物作为MTOR抑制剂
- Patent Title: Morpholino substituted urea or carbamate derivatives as MTOR inhibitors
- Patent Title (中): 吗啉取代的脲或氨基甲酸酯衍生物作为MTOR抑制剂
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Application No.: US14346332Application Date: 2012-09-21
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Publication No.: US09175011B2Publication Date: 2015-11-03
- Inventor: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , Mihiro Sunose , Adeline Morel , Laura Convery , Rita Adrego
- Applicant: CELLZOME LIMITED
- Applicant Address: GB Cambridge
- Assignee: CELLZONE LIMITED
- Current Assignee: CELLZONE LIMITED
- Current Assignee Address: GB Cambridge
- Agent Margaret M. Tomaska; Andrea V. Lockenour
- Priority: EP11182221 20110921
- International Application: PCT/EP2012/068590 WO 20120921
- International Announcement: WO2013/041652 WO 20130328
- Main IPC: C07D251/22
- IPC: C07D251/22 ; C07D401/12 ; C07D407/12 ; C07D413/04 ; C07D498/08 ; C07D413/14
Abstract:
The invention relates to compounds of formula (I) wherein m, n, R1, T0 and T1 have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as methods of treating mTOR related diseases.
Public/Granted literature
- US20140378438A1 MORPHOLINO SUBSTITUTED UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS Public/Granted day:2014-12-25
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