Invention Grant
US09175038B2 Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
有权
polo样激酶1 polo box结构域的肽模拟配体和使用方法
- Patent Title: Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
- Patent Title (中): polo样激酶1 polo box结构域的肽模拟配体和使用方法
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Application No.: US13320726Application Date: 2010-05-17
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Publication No.: US09175038B2Publication Date: 2015-11-03
- Inventor: Terrence R. Burke, Jr. , Fa Liu , Kyung S. Lee , Jung-Eun Park
- Applicant: Terrence R. Burke, Jr. , Fa Liu , Kyung S. Lee , Jung-Eun Park
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Locke Lord LLP
- Agent Bryan D. Zerhusen
- International Application: PCT/US2010/035069 WO 20100517
- International Announcement: WO2010/132869 WO 20101118
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A01K61/00 ; C07K7/06 ; A61K38/00
Abstract:
Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.
Public/Granted literature
- US20120065146A1 PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE Public/Granted day:2012-03-15
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