Invention Grant
US09175062B2 Human soluble receptor for advanced glycation end products (sRAGE), methods of preparing human sRAGE, and treatment methods using sRAGE
有权
用于晚期糖基化终产物（sRAGE）的人类可溶性受体，人sRAGE的制备方法和使用sRAGE的治疗方法
- Patent Title: Human soluble receptor for advanced glycation end products (sRAGE), methods of preparing human sRAGE, and treatment methods using sRAGE
- Patent Title (中): 用于晚期糖基化终产物（sRAGE）的人类可溶性受体，人sRAGE的制备方法和使用sRAGE的治疗方法
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Application No.: US14368374Application Date: 2013-01-03
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Publication No.: US09175062B2Publication Date: 2015-11-03
- Inventor: Li Lin , Sungha Park , Wen Wei , Rui-Ping Xiao , Mark I. Talan , Edward G. Lakatta
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2013/020103 WO 20130103
- International Announcement: WO2013/103688 WO 20130711
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K38/17
Abstract:
The present disclosure provides a method for recombinant production of human sRAGE in mammalian cells, as well as a human sRAGE having a mammalian post-translational modification and compositions thereof. The present disclosure also provides a method of treating a vascular disease, injury, or inflammation in a mammal by administering to a mammal with a vascular disease, injury, or inflammation a composition comprising human sRAGE having a mammalian post-translational modification, thereby treating the vascular disease, injury, or inflammation in the mammal.
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