Invention Grant
- Patent Title: Neutralizing antibodies to HIV-1 and their use
- Patent Title (中): 中和HIV-1的抗体及其用途
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Application No.: US13498125Application Date: 2010-09-24
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Publication No.: US09175070B2Publication Date: 2015-11-03
- Inventor: John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , William R. Schief
- Applicant: John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , William R. Schief
- Applicant Address: US DC Washington US WA Seattle
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Washington
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Washington
- Current Assignee Address: US DC Washington US WA Seattle
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2010/050295 WO 20100924
- International Announcement: WO2011/038290 WO 20110331
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61K31/517 ; A61K45/06
Abstract:
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
Public/Granted literature
- US20120282264A1 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE Public/Granted day:2012-11-08
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