Invention Grant
- Patent Title: Pharmaceutical composition for treatment and/or prophylaxis of cancer
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Application No.: US14236859Application Date: 2012-08-03
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Publication No.: US09175074B2Publication Date: 2015-11-03
- Inventor: Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
- Applicant: Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
- Applicant Address: JP Tokyo
- Assignee: TORAY INDUSTRIES, INC.
- Current Assignee: TORAY INDUSTRIES, INC.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2011-171377 20110804
- International Application: PCT/JP2012/069853 WO 20120803
- International Announcement: WO2013/018891 WO 20130207
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C07K16/18 ; A61K39/395 ; A61K45/06 ; C07K16/28 ; A61K39/00

Abstract:
An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
Public/Granted literature
- US20140154261A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER Public/Granted day:2014-06-05
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