Invention Grant
US09175085B2 Treatment of X-linked hypohidrotic ectodermal dysplasia with ectodysplasin A agonist
有权
用异位二磷脂A激动剂治疗X连锁的hypohidrotic外胚层发育不良
- Patent Title: Treatment of X-linked hypohidrotic ectodermal dysplasia with ectodysplasin A agonist
- Patent Title (中): 用异位二磷脂A激动剂治疗X连锁的hypohidrotic外胚层发育不良
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Application No.: US14117431Application Date: 2012-05-10
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Publication No.: US09175085B2Publication Date: 2015-11-03
- Inventor: Pascal Schneider , Christine Kowalczyk
- Applicant: Pascal Schneider , Christine Kowalczyk
- Applicant Address: US MA Cambridge
- Assignee: EDIMER PHARMACEUTICALS, INC.
- Current Assignee: EDIMER PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Dtward, PC
- Agent Donna T. Ward; Lingyun Jia
- International Application: PCT/US2012/037251 WO 20120510
- International Announcement: WO2012/158445 WO 20121122
- Main IPC: C07K14/715
- IPC: C07K14/715 ; A61K39/00 ; C07K16/28 ; C07K14/47
Abstract:
The invention relates to methods for the temporal administration of EDA agonists, in particular EDI200, which correlate to optimal therapeutic response windows required for the formation of any EDA-dependent structures such as ectodermal appendages. Use of the methods described allow for the design of targeted therapeutic dosing and administration regimens in order to correct or alter abnormal phenotypes associated with genetic disorders, in particular, XLHED.
Public/Granted literature
- US20150017161A1 COMPOSITIONS AND METHODS FOR THE ALTERATION OF XLHED PHENOTYPES Public/Granted day:2015-01-15
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