Invention Grant
- Patent Title: Method for inducing extended self-renewal of functionally differentiated somatic cells
- Patent Title (中): 诱导功能分化体细胞扩增自我更新的方法
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Application No.: US13382724Application Date: 2010-07-08
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Publication No.: US09175265B2Publication Date: 2015-11-03
- Inventor: Michael Sieweke
- Applicant: Michael Sieweke
- Applicant Address: FR Paris FR Paris FR Marseilles
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Centre National de la Recherche Scientifique (CNRS),Universite de la Mediterranee (Aix-Marseille II)
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM),Centre National de la Recherche Scientifique (CNRS),Universite de la Mediterranee (Aix-Marseille II)
- Current Assignee Address: FR Paris FR Paris FR Marseilles
- Agency: Whitham, Curtis, Christofferson & Cook, P.C.
- Priority: EP09305661 20090708
- International Application: PCT/EP2010/059843 WO 20100708
- International Announcement: WO2011/003988 WO 20110113
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N15/00 ; C12N15/63 ; A61K48/00 ; C07H21/04 ; C12N5/0786 ; C12N5/0781 ; C12N15/85 ; C12N15/86 ; C12N15/90 ; C12N5/078 ; A61K35/12
Abstract:
Mouse or human hematopoietic cells are transduced in vitro with one or more vectors encoding c-Myc and Klf4 genes, to overexpress both c-Myc and Klf4. The transduced cells produce self-renewing populations of macrophages, monocytes, monocyte-derived macrophages, B lymphocytes or erythroid cells. The self-renewing cell populations may include a pharmaceutical composition.
Public/Granted literature
- US20120156179A1 METHOD FOR INDUCING EXTENDED SELF-RENEWAL OF FUNCTIONALLY DIFFERENTIATED SOMATIC CELLS Public/Granted day:2012-06-21
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