Invention Grant
- Patent Title: Potent non-urea inhibitors of soluble epdxide hydrolase
- Patent Title (中): 可溶性Epdxide水解酶的非尿素抑制剂
-
Application No.: US14182175Application Date: 2014-02-17
-
Publication No.: US09175285B2Publication Date: 2015-11-03
- Inventor: Donald W. Landry , Yuli Xie , Yidong Lu , Gangli Gong , Shi-Xian Deng , Kirsten Alison Rinderspacher
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- Main IPC: C12N9/99
- IPC: C12N9/99 ; C07D211/96 ; C07D401/12 ; C07D409/12 ; C07D211/62 ; C07F9/59
Abstract:
The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.
Public/Granted literature
- US20140349368A1 POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE Public/Granted day:2014-11-27
Information query
