Invention Grant
US09176151B2 Antibodies, kit and method for detecting amyloid beta oligomers
有权
用于检测淀粉样β寡聚体的抗体，试剂盒和方法
- Patent Title: Antibodies, kit and method for detecting amyloid beta oligomers
- Patent Title (中): 用于检测淀粉样β寡聚体的抗体，试剂盒和方法
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Application No.: US13544600Application Date: 2012-07-09
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Publication No.: US09176151B2Publication Date: 2015-11-03
- Inventor: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
- Applicant: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
- Applicant Address: US CA Livermore
- Assignee: Acumen Pharmaceuticals, Inc.
- Current Assignee: Acumen Pharmaceuticals, Inc.
- Current Assignee Address: US CA Livermore
- Agency: Licata & Tyrrell P.C.
- Main IPC: C07K16/18
- IPC: C07K16/18 ; G01N33/532 ; G01N33/68
Abstract:
This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
Public/Granted literature
- US20130130288A1 Antibodies, Kit and Method for Detecting Amyloid Beta Oligomers Public/Granted day:2013-05-23
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